Toxics, Free Full-Text

Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research. Therefore, we direct this review to toxicologists who are considering male LUTD as a new aspect of chemical toxicity studies. We focus on the LUTD disease process in men, as well as in the male mouse as a leading research model. To introduce the disease process, we describe the physiology of the male lower urinary tract and the cellular composition of lower urinary tract tissues. We discuss known and suspected mechanisms of male LUTD and examples of environmental chemicals acting through these mechanisms to contribute to LUTD. We also describe mouse models of LUTD and endpoints to diagnose, characterize, and quantify LUTD in men and mice.

Green Toxic 3D editable text effect

It's impossible to be effective and feel fulfilled in a toxic

Toxics, Free Full-Text

Toxics, Free Full-Text, toxicity

Toxics, Free Full-Text, toxicity

Non-Toxic Images – Browse 10,312 Stock Photos, Vectors, and Video

Free PSD Toxic 3d editable text effect

Toxics, Free Full-Text, toxicity

Toxics, Free Full-Text, toxicity

Toxics, Free Full-Text

A Toxic Free Earth Day

Topic · Toxic chemicals ·

UV-328 Research Update - IPEN International Pollutants Elimination

Toxics, Free Full-Text

Toxics, Free Full-Text