Mitotane (2,4′-DDD), Antineoplastic Agent

Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions. - Mechanism of Action & Protocol.

Frontiers Complete Remission of Advanced Adrenocortical Cancer Following Mitotane Monotherapy: A Case Report and Literature Review of Predictive Markers

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Mitotane cancer drug molecule. Skeletal formula Stock Vector Image & Art - Alamy

Potentiation of mitotane action by rosuvastatin: New insights for adrenocortical carcinoma management

Adrenocortical carcinoma: a clinician's update

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PDF) Determination of Mitotane (DDD) and Principal Metabolite by a Simple HPLC-UV Method and Its Validation in Human Plasma Samples

mitotane - Wikidata

The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging

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Mitotane, C14H10Cl4

The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging

Neoplasm and Antineoplastic Agents

Exposure to anticancer drugs modulates the expression of ACSL4 and ABCG2 proteins in adrenocortical carcinoma cells - ScienceDirect