Yasmin Full Prescribing Information, Dosage & Side Effects
Yasmin(ethinylestradiol + drospirenone): YASMIN (drospirenone and ethinylestradiol) is indicated for: Conception control.
Each hormone-containing yellow, film-coated tablet contains 3.0 mg drospirenone and 0.030 mg ethinylestradiol.YASMIN (drospirenone and ethinylestradiol) tablets are available in a 21-day regimen.Drospirenone: Proper Name: drospirenone.Chemical Name: 6β, 7β; 15β, 16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone (IUPAC) [6R-(6α, 7α, 8β, 9α, 10β, 13β, 14α, 15α, 16α, 17β]-1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethylspiro[17H-dicyclopropa[6,7:15,16]cyclopenta[α]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione (USAN).Molecular Formula: C24H30O3.Molecular Weight: 366.50.Description: White to off-white crystalline powder. Freely soluble in dichloromethane; soluble in acetone, methanol, ethyl acetate, dimethoxyethane, and toluene; sparingly soluble in ethanol, and practically insoluble in water, n-hexane and diisopropyl ether. Melting range is 199°C to 201°C.pKa: Neutral molecule without any acid-base properties in aqueous solutions (pH 1 to 12).Partition coefficient: log POW = 3.08.Ethinylestradiol: Proper Name: ethinylestradiol.Chemical Name: 19-nor-17α-pregna-1,3,5(10)-triene-20-yne-3,17-diol (IUPAC).Molecular Formula: C20H24O2.Molecular Weight: 296.41.Description: White to yellowish-white crystals or crystalline powder. Freely soluble in ether, ethanol, acetone, and dioxane; soluble in chloroform and alkali hydroxide solutions; practically insoluble in water. Melting range is 181°C to 185°C.pKa: 10.25 ± 0.04.Partition Coefficient: log POW = 4.17 ± 0.03 (pH=5); 4.20 ± 0.04 (pH=7); 4.15 ± 0.04 (pH=9).Excipients/Inactive Ingredients: lactose monohydrate, maize starch, starch pre-gelatinized, povidone, magnesium stearate, hypromellose 5 cP, macrogol 6000, talc, titanium dioxide, ferric oxide yellow.
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