Clonal evolution in cancer
![Clonal evolution in cancer](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fnature10762/MediaObjects/41586_2012_Article_BFnature10762_Fig1_HTML.jpg)
Current leading models of carcinogenesis. (A) The clonal evolution
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A unified simulation model for understanding the diversity of cancer evolution [PeerJ]
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How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
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Prognostic value of clonal evolution identified by sequential FISH in untreated chronic lymphocytic leukaemia
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PIK3CA-CDKN2A clonal evolution in metastatic breast cancer and multiple points cell-free DNA analysis, Cancer Cell International
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Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future - ScienceDirect
![](https://www.researchgate.net/publication/323382382/figure/fig1/AS:960999431614519@1606131527884/Cancer-as-an-evolutionary-process-Clonal-evolution-in-cancer-is-driven-by-somatic-cell_Q320.jpg)
Cancer as an evolutionary process. Clonal evolution in cancer is driven
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Timing somatic events in the evolution of cancer, Genome Biology
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Evaluating statistical approaches to define clonal origin of tumours using bulk DNA sequencing: context is everything, Genome Biology
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IJMS, Free Full-Text
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Cancer as an evolutionary process. Clonal evolution in cancer is driven
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2 Tumor heterogeneity model. The first model or clonal evolution theory
![](https://maddipatilab.com/wp-content/uploads/2021/09/Tumor-heterogeneity.jpg)
Research - MADDIPATI LAB
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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - ScienceDirect
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Models of tumor heterogeneity. The clonal evolution theory was the